Mission Statement

The Mutagenic Mechanisms and Assessment Special Interest Group focuses on mutagenic mechanisms and the development, validation and application of methods to assess mutagenicity, including in laboratory animals, cell lines, and humans.

SIG Contact

If you would like more information, you can reach out to us here: Mutagenic Mechanisms & Assessment SIG Contact

If you are already an EMGS member and are interested in joining the Mutagenic Mechanisms and Assessment SIG:

Join the SIG

Search for the name of the group using the Find A Group search bar and click + Join Group.

Top Global Issues

• Understanding the diverse risk elements linked to the formation of nitrosamine drug substance related impurities (NDSRIs) in pharmaceuticals, and their potency of genotoxicity.  
• Promoting the adoption of newer and better technology (i.e. ecNGS) by regulatory agencies to replace the traditional mutation assay (i.e. TGR assay).  
• Developing methodology for defining acceptable limits for daily intake (AIs) by quantitative analysis of dose–response data from in vivo mutation assays.

SIG Membership

Any EMGS member may join the SIG, serve in a leadership role (SIG Chair/Co-Chair, SIG Representative to Program Committee, Student and Early Career Investigator Co-Chair (SECI), and have voting privileges. Any EMGS Annual Meeting attendees who are not EMGS members and/or SIG members are welcome to attend the SIG meeting at the Annual Meeting. EMGS members may join or leave the SIG at any time, are encouraged to check on their membership status on the EMGS website and can ask SIG leadership to update their membership status as necessary. EMGS members may belong to as many SIGs as they choose, and SIG memberships are free of charge. 

SIG Leadership

Leadership roles in this SIG include a Chair, Co-Chair (optional), Student and Early Career Investigator (SECI) Co-Chair, and a Representative to the Program Committee. Starting in February 2020, the responsibilities for these roles and the timelines and procedures for nominations and elections has been standardized across all EMGS SIGs. 

SIG Files

Mutagenic Mechanisms and Assessment SOP | EMGS Strategic Plan | 2024 Top Global Issues